<?xml version="1.0" encoding="UTF-8"?><ArtifactAssessment xmlns="http://hl7.org/fhir"><id value="example-certainty-rating"/><text><status value="generated"/><div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: ArtifactAssessment</b><a name="example-certainty-rating"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource ArtifactAssessment &quot;example-certainty-rating&quot; </p></div><p><b>identifier</b>: FEvIR Object Identifier: 27756</p><p><b>date</b>: 2021-11-02T14:48:59.89Z</p><p><b>copyright</b>: https://creativecommons.org/licenses/by-nc-sa/4.0/</p><p><b>artifact</b>: <a href="broken-link.html">Evidence/18812: Critically appraised summary of all-cause mortality in meta-analysis of RCTs of heparin for moderately ill patients with COVID-19</a></p><blockquote><p><b>content</b></p><p><b>informationType</b>: rating</p><p><b>summary</b>: serious concerns with risk of bias, inconsistency, and imprecision</p><p><b>type</b>: Overall certainty <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="codesystem-certainty-type.html">Evidence Certainty Type</a>#Overall)</span></p><p><b>classifier</b>: Very low quality <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="codesystem-certainty-rating.html">Evidence Certainty Rating</a>#very-low)</span></p><p><b>author</b>: <span>: Brian S. Alper</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class="grid"><tr><td>-</td><td><b>InformationType</b></td><td><b>Summary</b></td><td><b>Type</b></td><td><b>Classifier</b></td><td><b>Author</b></td></tr><tr><td>*</td><td>rating</td><td>risk of bias in both included trials</td><td>Risk of bias <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="codesystem-certainty-type.html">Evidence Certainty Type</a>#RiskOfBias)</span></td><td>serious concern <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="codesystem-certainty-rating.html">Evidence Certainty Rating</a>#serious-concern)</span></td><td><span>: Brian S. Alper</span></td></tr><tr><td>*</td><td>rating</td><td>high degree of heterogeneity (I-squared 80.7%) with confidence intervals of 2 trial effect estimates barely overlapping</td><td>Inconsistency <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="codesystem-certainty-type.html">Evidence Certainty Type</a>#Inconsistency)</span></td><td>serious concern <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="codesystem-certainty-rating.html">Evidence Certainty Rating</a>#serious-concern)</span></td><td><span>: Brian S. Alper</span></td></tr><tr><td>*</td><td>rating</td><td> </td><td>Indirectness <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="codesystem-certainty-type.html">Evidence Certainty Type</a>#Indirectness)</span></td><td>no serious concern <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="codesystem-certainty-rating.html">Evidence Certainty Rating</a>#no-concern)</span></td><td><span>: Brian S. Alper</span></td></tr><tr><td>*</td><td>rating</td><td>95% confidence interval includes both large effects and no effects</td><td>Imprecision <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="codesystem-certainty-type.html">Evidence Certainty Type</a>#Imprecision)</span></td><td>serious concern <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="codesystem-certainty-rating.html">Evidence Certainty Rating</a>#serious-concern)</span></td><td><span>: Brian S. Alper</span></td></tr><tr><td>*</td><td>rating</td><td> </td><td>Publication bias <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="codesystem-certainty-type.html">Evidence Certainty Type</a>#PublicationBias)</span></td><td>no serious concern <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="codesystem-certainty-rating.html">Evidence Certainty Rating</a>#no-concern)</span></td><td><span>: Brian S. Alper</span></td></tr></table></blockquote></div></text><identifier><type><text value="FEvIR Object Identifier"/></type><system value="https://fevir.net"/><value value="27756"/><assigner><display value="Computable Publishing LLC"/></assigner></identifier><date value="2021-11-02T14:48:59.890Z"/><copyright value="https://creativecommons.org/licenses/by-nc-sa/4.0/"/><artifactReference><reference value="Evidence/18812"/><type value="Evidence"/><display value="Critically appraised summary of all-cause mortality in meta-analysis of RCTs of heparin for moderately ill patients with COVID-19"/></artifactReference><content><informationType value="rating"/><summary value="serious concerns with risk of bias, inconsistency, and imprecision"/><type><coding><system value="http://hl7.org/fhir/certainty-type"/><code value="Overall"/><display value="Overall certainty"/></coding></type><classifier><coding><system value="http://hl7.org/fhir/certainty-rating"/><code value="very-low"/><display value="Very low quality"/></coding></classifier><author><display value="Brian S. Alper"/></author><freeToShare value="true"/><component><informationType value="rating"/><summary value="risk of bias in both included trials"/><type><coding><system value="http://hl7.org/fhir/certainty-type"/><code value="RiskOfBias"/><display value="Risk of bias"/></coding></type><classifier><coding><system value="http://hl7.org/fhir/certainty-rating"/><code value="serious-concern"/><display value="serious concern"/></coding></classifier><author><display value="Brian S. Alper"/></author></component><component><informationType value="rating"/><summary value="high degree of heterogeneity (I-squared 80.7%) with confidence intervals of 2 trial effect estimates barely overlapping"/><type><coding><system value="http://hl7.org/fhir/certainty-type"/><code value="Inconsistency"/><display value="Inconsistency"/></coding></type><classifier><coding><system value="http://hl7.org/fhir/certainty-rating"/><code value="serious-concern"/><display value="serious concern"/></coding></classifier><author><display value="Brian S. Alper"/></author></component><component><informationType value="rating"/><type><coding><system value="http://hl7.org/fhir/certainty-type"/><code value="Indirectness"/><display value="Indirectness"/></coding></type><classifier><coding><system value="http://hl7.org/fhir/certainty-rating"/><code value="no-concern"/><display value="no serious concern"/></coding></classifier><author><display value="Brian S. Alper"/></author></component><component><informationType value="rating"/><summary value="95% confidence interval includes both large effects and no effects"/><type><coding><system value="http://hl7.org/fhir/certainty-type"/><code value="Imprecision"/><display value="Imprecision"/></coding></type><classifier><coding><system value="http://hl7.org/fhir/certainty-rating"/><code value="serious-concern"/><display value="serious concern"/></coding></classifier><author><display value="Brian S. Alper"/></author></component><component><informationType value="rating"/><type><coding><system value="http://hl7.org/fhir/certainty-type"/><code value="PublicationBias"/><display value="Publication bias"/></coding></type><classifier><coding><system value="http://hl7.org/fhir/certainty-rating"/><code value="no-concern"/><display value="no serious concern"/></coding></classifier><author><display value="Brian S. Alper"/></author></component></content></ArtifactAssessment>