<?xml version="1.0" encoding="UTF-8"?><ArtifactAssessment xmlns="http://hl7.org/fhir">
    <id value="example-certainty-rating"/>
	<text><status value="generated"/><div xmlns="http://www.w3.org/1999/xhtml"><p><b>Generated Narrative: ArtifactAssessment</b><a name="example-certainty-rating"> </a></p><div style="display: inline-block; background-color: #d9e0e7; padding: 6px; margin: 4px; border: 1px solid #8da1b4; border-radius: 5px; line-height: 60%"><p style="margin-bottom: 0px">Resource ArtifactAssessment &quot;example-certainty-rating&quot; </p></div><p><b>identifier</b>: FEvIR Object Identifier: 27756</p><p><b>date</b>: 2021-11-02T14:48:59.89Z</p><p><b>copyright</b>: https://creativecommons.org/licenses/by-nc-sa/4.0/</p><p><b>artifact</b>: <a href="broken-link.html">Evidence/18812: Critically appraised summary of all-cause mortality in meta-analysis of RCTs of heparin for moderately ill patients with COVID-19</a></p><blockquote><p><b>content</b></p><p><b>informationType</b>: rating</p><p><b>summary</b>: serious concerns with risk of bias, inconsistency, and imprecision</p><p><b>type</b>: Overall certainty <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="codesystem-certainty-type.html">Evidence Certainty Type</a>#Overall)</span></p><p><b>classifier</b>: Very low quality <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="codesystem-certainty-rating.html">Evidence Certainty Rating</a>#very-low)</span></p><p><b>author</b>: <span>: Brian S. Alper</span></p><p><b>freeToShare</b>: true</p><h3>Components</h3><table class="grid"><tr><td>-</td><td><b>InformationType</b></td><td><b>Summary</b></td><td><b>Type</b></td><td><b>Classifier</b></td><td><b>Author</b></td></tr><tr><td>*</td><td>rating</td><td>risk of bias in both included trials</td><td>Risk of bias <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="codesystem-certainty-type.html">Evidence Certainty Type</a>#RiskOfBias)</span></td><td>serious concern <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="codesystem-certainty-rating.html">Evidence Certainty Rating</a>#serious-concern)</span></td><td><span>: Brian S. Alper</span></td></tr><tr><td>*</td><td>rating</td><td>high degree of heterogeneity (I-squared 80.7%) with confidence intervals of 2 trial effect estimates barely overlapping</td><td>Inconsistency <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="codesystem-certainty-type.html">Evidence Certainty Type</a>#Inconsistency)</span></td><td>serious concern <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="codesystem-certainty-rating.html">Evidence Certainty Rating</a>#serious-concern)</span></td><td><span>: Brian S. Alper</span></td></tr><tr><td>*</td><td>rating</td><td> </td><td>Indirectness <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="codesystem-certainty-type.html">Evidence Certainty Type</a>#Indirectness)</span></td><td>no serious concern <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="codesystem-certainty-rating.html">Evidence Certainty Rating</a>#no-concern)</span></td><td><span>: Brian S. Alper</span></td></tr><tr><td>*</td><td>rating</td><td>95% confidence interval includes both large effects and no effects</td><td>Imprecision <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="codesystem-certainty-type.html">Evidence Certainty Type</a>#Imprecision)</span></td><td>serious concern <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="codesystem-certainty-rating.html">Evidence Certainty Rating</a>#serious-concern)</span></td><td><span>: Brian S. Alper</span></td></tr><tr><td>*</td><td>rating</td><td> </td><td>Publication bias <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="codesystem-certainty-type.html">Evidence Certainty Type</a>#PublicationBias)</span></td><td>no serious concern <span style="background: LightGoldenRodYellow; margin: 4px; border: 1px solid khaki"> (<a href="codesystem-certainty-rating.html">Evidence Certainty Rating</a>#no-concern)</span></td><td><span>: Brian S. Alper</span></td></tr></table></blockquote></div></text><identifier>
		<type>
			<text value="FEvIR Object Identifier"/>
		</type>
		<system value="https://fevir.net"/>
		<value value="27756"/>
		<assigner>
			<display value="Computable Publishing LLC"/>
		</assigner>
	</identifier>
	<date value="2021-11-02T14:48:59.890Z"/>
	<copyright value="https://creativecommons.org/licenses/by-nc-sa/4.0/"/>
	<artifactReference>
		<reference value="Evidence/18812"/>
		<type value="Evidence"/>
		<display value="Critically appraised summary of all-cause mortality in meta-analysis of RCTs of heparin for moderately ill patients with COVID-19"/>
	</artifactReference>
	<content>
		<informationType value="rating"/>
		<summary value="serious concerns with risk of bias, inconsistency, and imprecision"/>
		<type>
			<coding>
				<system value="http://hl7.org/fhir/certainty-type"/>
				<code value="Overall"/>
				<display value="Overall certainty"/>
			</coding>
		</type>
		<classifier>
			<coding>
				<system value="http://hl7.org/fhir/certainty-rating"/>
				<code value="very-low"/>
				<display value="Very low quality"/>
			</coding>
		</classifier>
		<author>
			<display value="Brian S. Alper"/>
		</author>
		<freeToShare value="true"/>
		<component>
			<informationType value="rating"/>
			<summary value="risk of bias in both included trials"/>
			<type>
				<coding>
					<system value="http://hl7.org/fhir/certainty-type"/>
					<code value="RiskOfBias"/>
					<display value="Risk of bias"/>
				</coding>
			</type>
			<classifier>
				<coding>
					<system value="http://hl7.org/fhir/certainty-rating"/>
					<code value="serious-concern"/>
					<display value="serious concern"/>
				</coding>
			</classifier>
			<author>
				<display value="Brian S. Alper"/>
			</author>
		</component>
		<component>
			<informationType value="rating"/>
			<summary value="high degree of heterogeneity (I-squared 80.7%) with confidence intervals of 2 trial effect estimates barely overlapping"/>
			<type>
				<coding>
					<system value="http://hl7.org/fhir/certainty-type"/>
					<code value="Inconsistency"/>
					<display value="Inconsistency"/>
				</coding>
			</type>
			<classifier>
				<coding>
					<system value="http://hl7.org/fhir/certainty-rating"/>
					<code value="serious-concern"/>
					<display value="serious concern"/>
				</coding>
			</classifier>
			<author>
				<display value="Brian S. Alper"/>
			</author>
		</component>
		<component>
			<informationType value="rating"/>
			<type>
				<coding>
					<system value="http://hl7.org/fhir/certainty-type"/>
					<code value="Indirectness"/>
					<display value="Indirectness"/>
				</coding>
			</type>
			<classifier>
				<coding>
					<system value="http://hl7.org/fhir/certainty-rating"/>
					<code value="no-concern"/>
					<display value="no serious concern"/>
				</coding>
			</classifier>
			<author>
				<display value="Brian S. Alper"/>
			</author>
		</component>
		<component>
			<informationType value="rating"/>
			<summary value="95% confidence interval includes both large effects and no effects"/>
			<type>
				<coding>
					<system value="http://hl7.org/fhir/certainty-type"/>
					<code value="Imprecision"/>
					<display value="Imprecision"/>
				</coding>
			</type>
			<classifier>
				<coding>
					<system value="http://hl7.org/fhir/certainty-rating"/>
					<code value="serious-concern"/>
					<display value="serious concern"/>
				</coding>
			</classifier>
			<author>
				<display value="Brian S. Alper"/>
			</author>
		</component>
		<component>
			<informationType value="rating"/>
			<type>
				<coding>
					<system value="http://hl7.org/fhir/certainty-type"/>
					<code value="PublicationBias"/>
					<display value="Publication bias"/>
				</coding>
			</type>
			<classifier>
				<coding>
					<system value="http://hl7.org/fhir/certainty-rating"/>
					<code value="no-concern"/>
					<display value="no serious concern"/>
				</coding>
			</classifier>
			<author>
				<display value="Brian S. Alper"/>
			</author>
		</component>
	</content>
</ArtifactAssessment>