{"description":"2.7% incidence of fatal intracranial hemorrhage within 7 days with alteplase in patients with acute ischemic stroke","id":"example-stroke-alteplase-fatalICH","identifier":[{"system":"urn:ietf:rfc:3986","value":"urn:oid:2.16.840.1.113883.4.642.10.1"}],"name":"RiskOfFatalICHWithAlteplaseForStroke","relatedArtifact":[{"citation":"Emberson J, Lees KR, Lyden P, Blackwell L, Albers G, Bluhmki E, et al;Stroke Thrombolysis Trialists' Collaborative Group. Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials. Lancet 2014 Nov 29;384(9958):1929-35 PMID 25106063","display":"Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials.","document":{"url":"https://doi.org/10.1016/S0140-6736(14)60584-5"},"label":"Emberson 2014","type":"citation"}],"resourceType":"Evidence","statistic":[{"numberOfEvents":91,"quantity":{"value":0.026835741669},"sampleSize":{"numberOfParticipants":3391,"numberOfStudies":9},"statisticType":{"coding":[{"code":"C44256","display":"Proportion","system":"http://terminology.hl7.org/CodeSystem/statistic-type"}]}}],"status":"draft","studyDesign":[{"coding":[{"code":"SEVCO:01003","display":"randomized assignment","system":"http://hl7.org/fhir/study-design"}]}],"synthesisType":{"coding":[{"code":"IPD-MA","display":"individual patient data meta-analysis","system":"http://terminology.hl7.org/CodeSystem/synthesis-type"}]},"text":{"div":"<div xmlns=\"http://www.w3.org/1999/xhtml\">\n      \n      <p>\n        &quot;Risk of fatal ICH with alteplase for stroke&quot; is a univariate risk estimate.\n      </p>\n\t\n    </div>","status":"generated"},"title":"Risk of fatal ICH with alteplase for stroke","url":"http://hl7.org/fhir/Evidence/example-stroke-alteplase-fatalICH","variableDefinition":[{"intended":{"display":"adults with acute ischemic stroke","reference":"Group/AcuteIschemicStroke","type":"Group"},"observed":{"display":"adults with acute ischemic stroke","reference":"Group/AcuteIschemicStroke","type":"Group"},"variableRole":{"coding":[{"code":"population","display":"population","system":"http://terminology.hl7.org/CodeSystem/variable-role"}]}},{"intended":{"display":"adults with acute ischemic stroke treated with alteplase","reference":"Group/AcuteIschemicStrokeTreatedWithAlteplase","type":"Group"},"observed":{"display":"Emberson 2014 IPD-MA Alteplase Cohort","reference":"Group/Emberson-2014-IPD-MA-Alteplase-Cohort","type":"Group"},"variableRole":{"coding":[{"code":"population","display":"population","system":"http://terminology.hl7.org/CodeSystem/variable-role"}]}},{"intended":{"display":"fatal ICH","reference":"EvidenceVariable/example-fatal-ICH-in-7-days","type":"EvidenceVariable"},"observed":{"display":"fatal ICH","reference":"EvidenceVariable/example-fatal-ICH-in-7-days","type":"EvidenceVariable"},"variableRole":{"coding":[{"code":"measuredVariable","display":"measured variable","system":"http://terminology.hl7.org/CodeSystem/variable-role"}]}}]}