Name	Flags	Card.	Type	Description & Constraints
ClinicalUseDefinition	TU		DomainResource	A single issue - either an indication, contraindication, interaction or an undesirable effect for a medicinal product, medication, device or procedure + Rule: Indication, Contraindication, Interaction, UndesirableEffect and Warning cannot be used in the same instance Elements defined in Ancestors: id, meta, implicitRules, language, text, contained, extension, modifierExtension
identifier	Σ	0..*	Identifier	Business identifier for this issue
type	Σ	1..1	code	indication | contraindication | interaction | undesirable-effect | warning Binding: Clinical Use Definition Type (Required)
category	Σ	0..*	CodeableConcept	A categorisation of the issue, primarily for dividing warnings into subject heading areas such as "Pregnancy", "Overdose" Binding: Clinical Use Definition Category (Preferred)
subject	Σ	0..*	Reference(MedicinalProductDefinition | Medication | ActivityDefinition | PlanDefinition | Device | DeviceDefinition | Substance | NutritionProduct | BiologicallyDerivedProduct)	The medication, product, substance, device, procedure etc. for which this is an indication
status	Σ	0..1	CodeableConcept	Whether this is a current issue or one that has been retired etc Binding: PublicationStatus (Preferred)
contraindication	ΣC	0..1	BackboneElement	Specifics for when this is a contraindication
diseaseSymptomProcedure	Σ	0..1	CodeableReference(ObservationDefinition)	The situation that is being documented as contraindicating against this item Binding: Disease Symptom Procedure (Example)
diseaseStatus	Σ	0..1	CodeableReference(ObservationDefinition)	The status of the disease or symptom for the contraindication Binding: Disease Status (Example)
comorbidity	Σ	0..*	CodeableReference(ObservationDefinition)	A comorbidity (concurrent condition) or coinfection Binding: Disease Symptom Procedure (Example)
indication	Σ	0..*	Reference(ClinicalUseDefinition)	The indication which this is a contraidication for
applicability		0..1	Expression	An expression that returns true or false, indicating whether the indication is applicable or not, after having applied its other elements
otherTherapy	Σ	0..*	BackboneElement	Information about use of the product in relation to other therapies described as part of the contraindication
relationshipType	Σ	1..1	CodeableConcept	The type of relationship between the product indication/contraindication and another therapy Binding: Therapy Relationship Type (Preferred)
treatment	Σ	1..1	CodeableReference(MedicinalProductDefinition | Medication | Substance | SubstanceDefinition | NutritionProduct | BiologicallyDerivedProduct | ActivityDefinition)	Reference to a specific medication, substance etc. as part of an indication or contraindication Binding: Therapy (Example)
indication	ΣC	0..1	BackboneElement	Specifics for when this is an indication
diseaseSymptomProcedure	Σ	0..1	CodeableReference(ObservationDefinition)	The situation that is being documented as an indicaton for this item Binding: Disease Symptom Procedure (Example)
diseaseStatus	Σ	0..1	CodeableReference(ObservationDefinition)	The status of the disease or symptom for the indication Binding: Disease Status (Example)
comorbidity	Σ	0..*	CodeableReference(ObservationDefinition)	A comorbidity or coinfection as part of the indication Binding: Disease Symptom Procedure (Example)
intendedEffect	Σ	0..1	CodeableReference(ObservationDefinition)	The intended effect, aim or strategy to be achieved Binding: Product Intended Use (Preferred)
duration[x]	Σ	0..1		Timing or duration information
durationRange			Range
durationString			string
undesirableEffect	Σ	0..*	Reference(ClinicalUseDefinition)	An unwanted side effect or negative outcome of the subject of this resource when being used for this indication
applicability		0..1	Expression	An expression that returns true or false, indicating whether the indication is applicable or not, after having applied its other elements
otherTherapy	Σ	0..*	see otherTherapy	The use of the medicinal product in relation to other therapies described as part of the indication
interaction	ΣC	0..1	BackboneElement	Specifics for when this is an interaction
interactant	Σ	0..*	BackboneElement	The specific medication, product, food etc. or laboratory test that interacts
item[x]	Σ	1..1		The specific medication, product, food etc. or laboratory test that interacts Binding: Interactant (Example)
itemReference			Reference(MedicinalProductDefinition | Medication | Substance | NutritionProduct | BiologicallyDerivedProduct | ObservationDefinition)
itemCodeableConcept			CodeableConcept
type	Σ	0..1	CodeableConcept	The type of the interaction e.g. drug-drug interaction, drug-lab test interaction Binding: Interaction Type (Example)
effect	Σ	0..1	CodeableReference(ObservationDefinition)	The effect of the interaction, for example "reduced gastric absorption of primary medication" Binding: Interaction Effect (Example)
incidence	Σ	0..1	CodeableConcept	The incidence of the interaction, e.g. theoretical, observed Binding: Interaction Incidence (Example)
management	Σ	0..*	CodeableConcept	Actions for managing the interaction Binding: Interaction Management (Example)
population	Σ	0..*	Reference(Group)	The population group to which this applies
library	Σ	0..*	canonical(Library)	Logic used by the clinical use definition
undesirableEffect	ΣC	0..1	BackboneElement	A possible negative outcome from the use of this treatment
symptomConditionEffect	Σ	0..1	CodeableReference(ObservationDefinition)	The situation in which the undesirable effect may manifest Binding: Undesirable Effect Symptom (Example)
classification	Σ	0..1	CodeableConcept	High level classification of the effect Binding: Undesirable Effect Classification (Example)
frequencyOfOccurrence	Σ	0..1	CodeableConcept	How often the effect is seen Binding: Undesirabl Effect Frequency (Example)
warning	ΣC	0..1	BackboneElement	Critical environmental, health or physical risks or hazards. For example 'Do not operate heavy machinery', 'May cause drowsiness'
description	Σ	0..1	markdown	A textual definition of this warning, with formatting
code	Σ	0..1	CodeableConcept	A coded or unformatted textual definition of this warning Binding: Warning Type (Example)
Documentation for this format